Hepatitis

LIVER HEPATITIS A, B, C, D & E VIRUS DISEASES TREATMENTS

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Hepatitis A & Hepatitis E

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Hepatitis A

Both the viruses (hepatitis A and E) are spread via food or water contaminated with fecal matter, principally in areas of poor sanitation and simple water purification such as boiling water, washing hands after using the toilet etc will control the disease spread as well as prevent it.

Symptoms:

Jaundice, Tiredness, oss of appetite, Distaste of food, Itching

Diagnosis & severity assessment:

  • IgM HAV antibody for Hepatitis A virus
  • IgM HEV antibody for Hepatitis E virus
  • Liver function test, Prothromin time, USG abdomen

Prevention:

A safe and effective hepatitis A vaccine is available and is recommended for patients at high risk patients such as chronic liver disease or patients with chronic immunodeficiency or those on dialysis, and those on chronic immunosuppressive therapies.

Hepatitis B

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Hepatitis B

“Hepatitis” means inflammation of the liver. Whenever the liver is inflamed or damaged, it will lose its function. Hepatitis B virus is one of virus which will cause of serious liver disease over the period of time.

Acute Hepatitis B refers to a short-term infection that occurs within the first 6 months after someone is infected with the virus. It can range in severity from a mild illness with few or no symptoms to a serious condition requiring hospitalization. Some people, especially adults, are able to clear, or get rid of, the virus without treatment. People who clear the virus become immune and cannot get infected with the Hepatitis B virus again.

Chronic Hepatitis B refers to a lifelong infection with the Hepatitis B virus. Up to 90% of infants infected with the Hepatitis B virus will develop a chronic infection. In contrast, about 5% of adults will develop chronic Hepatitis B. Chronic Hepatitis B can cause liver damage, cirrhosis, liver cancer, and even death.

Mode of spread:

Many people with Hepatitis B virus do not develop any symptoms until the stage of decompensated chronic liver disease. Most common and early symptom is fatigue or tiredness.

Stages:

  • HBsAg carrier
  • Chronic hepatitis B
  • Chronic liver disease
  • Hepatocellular carcinoma (Liver cancer)

Tests to confirm the disease & severity of the disease:

HBsAg, USG abdomen or CT abdomen with triphasic study, HBV DNA quantification assay, Alfa fetoprotein.

Treatment:

Anti-viral drugs

Family members screening & Vaccination:

The best way to prevent Hepatitis B is by getting vaccination which will provide life-long immunity against the virus.

Hepatitis C

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Hepatitis C

Hepatitis C virus disease is a curable disease at initial stage. Similar to Hepatitis B virus, hepatitis C virus is one of the virus which will transmit through blood & blood products, unsafe sex and contaminated needles/ syringes, etc.

There is no evidence that kissing or hugging, sneezing or coughing, sharing food /water or through eating utensils/drinking glasses lead to transmission of hepatitis C virus

Acute versus chronic hepatitis C infection — when people are first infected with the hepatitis C virus, they develop acute hepatitis which mostly progress to chronic infection (i.e) virus will persist for more than 6 months.

Symptoms:

Most people with hepatitis C have no symptom or only mild nonspecific symptom such as Fatigue

Diagnosis & severity assessment:

Blood tests such as Anti HCV, HCV RNA quantification, USG abdomen or CT abdomen with triphasic study, Alfa feto-protein

Treatment:

Anti-viral drugs